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Cell-specific Expression of the Neuron-Restrictive silencing Factor (NRSF)
Reference
G12761
Principal Investigator / Supervisor
Professor Noel Buckley
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
178,652
Status
Completed
Type
Research Grant
Start date
01/08/2000
End date
01/08/2003
Duration
36 months
Abstract
Differentiation of the mammalian nervous system is accompanied by massive changes in neuronal gene expression. One transcription factor that has been proposed to be intimately involved in this process is the neuron-restrictive silencing factor (NRSF), a zinc finger transcription factor that interacts with the neuron-restrictive silencer element (NRSE), and is responsible for silencing differentiated neuronal gene expression in both non- neuronal cells and in neuronal progenitors. Transgenes bearing mutated NRSEs display aberrant expression profiles and NRSF-/- mice die in mid-gestation. This proposal is designed to characterise regulatory cis elements and cognate transcription factors that govern cell specific expression of NRSF in order to understand how this molecule contributes to the establishment of differentiated neuronal phenotype.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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