Award details

The A-domain proteins of C. elegans: a novel family of extracellular matrix molecules?

Reference	G12717
Principal Investigator / Supervisor	Dr Daniel Tuckwell
Co-Investigators / Co-Supervisors	Dr Gordon. Lithgow
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	96,312
Status	Completed
Type	Research Grant
Start date	06/02/2000
End date	06/02/2003
Duration	36 months

Abstract

The nematode C. elegans produces two extracellular matrices (ECMs), cuticle and basement membrane. These specify organism shape, influence mode of motion and underpin tissue organisation. Our analysis of the new completed C. elegans genome identified a novel family of 8 proteins containing 'A-domain' modules. We propose these are components of the ECM which may play a key role in its organisation. This project aims to determine the function of these proteins by (i) Using RNA interference experiments, knock-outs and mutant strains to disrupt function; (ii) Using reporter gene fusions and PCR to determine times and sites of expression. This will further our understanding of ECM organisation in C. elegans and in other organisms.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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