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The molecular control of pronephros development
Reference
G12713
Principal Investigator / Supervisor
Professor Elizabeth Jones
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
180,324
Status
Completed
Type
Research Grant
Start date
15/05/2000
End date
15/05/2003
Duration
36 months
Abstract
The aim of this proposal is to investigate the molecular induction and patterning events that direct the formation of the larval Amphibian kidney, the pronephros. The investigation will proceed following a subtractive hybridisation strategy designed to enrich for these gene sequences. A functional approach using combination of target over-expression and RNAI interference will identify the role of the identified clones in pronephros induction and patterning. In addition, a biological study on the role of Wnt 4 and 11 in pronephros development together with a study on glomus specification will add to the understanding of how the earliest vertebrate kidney form, the pronephros, develops.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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