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Genetic analysis of quantitative traits

Reference	G12499
Principal Investigator / Supervisor	Professor William George Hill
Co-Investigators / Co-Supervisors	Professor Grahame Bulfield, Dr Lutz Bunger, Professor Peter Keightley
Institution	University of Edinburgh
Department	Inst of Cell, Animal and Population Biol
Funding type	Research
Value (£)	393,198
Status	Completed
Type	Research Grant
Start date	01/04/2000
End date	01/04/2003
Duration	36 months

Abstract

We have established and will maintain a set of extreme lines of mice produced by divergent selection from the same base population for over 60 generations for growth, fatness and metabolic rate. Inbred lines have been developed from the selection lines. In addition, growth selected lines from other labs world-wide have been brought in. They provide a unique and powerful resource for analysis of these quantitative traits, mapping QTL and identifying the relevant genes. For fine mapping of QTL, congenic lines will be developed by backcrossing and candidate genes will be tested using knock-outs. The resource will be used in collaborative studies with other labs for genetic analysis of growth, obesity, metabolic rate, and related traits.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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