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Investigating key retinoid-responsive genes in early development: the establishment of a retinoid -deficient quail facility

Reference	G12414
Principal Investigator / Supervisor	Professor Malcolm Maden
Co-Investigators / Co-Supervisors	Dr Emily Gale
Institution	King's College London
Department	Reproductive Health Endocrinology Dev
Funding type	Research
Value (£)	88,732
Status	Completed
Type	Research Grant
Start date	01/12/2000
End date	15/03/2002
Duration	16 months

Abstract

We propose to establish as a nationally available facility a vitamin A-deficient quail colony to provide retinoid-deficient embryos for the study of retinoid-responsive and developmentally important genes throughout the embryo. In our work and in collaborations we have already established we will study the role of retinoids and identifying developmental genes involved in the development of the hindbrain, forebrain, neural crest, limbs, somites and lateral plate mesoderm. Other organ systems of the embryo which are so far unstudied are the heart, the eye and the gut and we expect that once our facility becomes established these systems will become additional foci of research. This is a novel and economical method for identifying developmentally important genes whose function can then be tested with electroporation techniques which now work on quail embryos.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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