Award details

Commissureless mediated regulation of cell surface molecules

Reference	G12134
Principal Investigator / Supervisor	Professor Guy Justin Clive Tear
Co-Investigators / Co-Supervisors
Institution	King's College London
Department	GKT School of Medicine
Funding type	Research
Value (£)	151,483
Status	Completed
Type	Research Grant
Start date	01/05/2000
End date	01/05/2003
Duration	36 months

Abstract

During the development of the nervous system axons extend over long distances to reach their target. Throughout this migration the growth cone encounters a number of different guidance cues. The growth cone may also react differentially to the same cues at particular choice points in order to redirect its trajectory. This differential behaviour may be achieved by changes in the surface properties of the growth cone. Commissureless (comm) is a protein that acts in Drosophila to regulate the levels of a guidance cue receptor, Roundabout (robo). We wish to identify how Comm regulates Robo levels and whether it can regulate other surface proteins. We have preliminary evidence that Comm associates with a ubiquitin ligase, D-Nedd4. This suggests Comm may target proteins to the ubiquitination pathway. We hope to test these ideas both in vitro and in vivo.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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