Award details

A global survey of gene expression changes accompanying senescence in Drosophila

Reference	G12125
Principal Investigator / Supervisor	Professor D Goldstein
Co-Investigators / Co-Supervisors	Professor Linda Partridge
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	346,108
Status	Completed
Type	Research Grant
Start date	23/06/2000
End date	23/06/2003
Duration	36 months

Abstract

Microarray systems will be used to quantify changes in gene expression associated senescence in Drosophila melanogaster. Expression profiles will be evaluated in wild-type lines, long-lived lines, and in oxidative-damage control mutants as well as in wild-type D. simulans and D. sechellia. These profiles will enable us to address a number of outstanding questions concerning the biology of senescence including: 1) What are the patterns of change in gene expression during normal senescence, and what changes are causal? 2) Are expression profiles associated with senescence conserved across species? And 3) how important is oxidative damage in normal senescence?

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search