BBSRC Portfolio Analyser
Award details
Studies of the roles of the JAK2 protein tyrosine kinase in cellular survival decisions
Reference
G12109
Principal Investigator / Supervisor
Professor Alan Clarke
Co-Investigators /
Co-Supervisors
Dr James Matthews
,
Professor Christine Watson
Institution
Cardiff University
Department
School of Biosciences
Funding type
Research
Value (£)
278,688
Status
Completed
Type
Research Grant
Start date
01/02/2000
End date
13/03/2003
Duration
37 months
Abstract
The JAK2 protein tyrosine kinase transmits anti-apoptotic signals in a number of systems, this study combines gene knockout and biochemical approaches to probe the role of JAK2 in cellular decisions to proliferate or enter apoptosis. We will generate homozygous floxed JAK2 mice to study JAK2's role in cell survival in vivo. We will also use nullizygous JAK2 murine embryonic stem cell clones for in vitro studies of cell survival, for haematopoietic reconstitution experiments, and to generate chimaeric mice to explore JAK2's role in the whole animal.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search