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Regulation of individual muscle patterning in vertebrate limbs during development
Reference
G11936
Principal Investigator / Supervisor
Professor Emeritus Cheryll Tickle
Co-Investigators /
Co-Supervisors
Dr Peter Ashby
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
209,950
Status
Completed
Type
Research Grant
Start date
01/03/2000
End date
01/03/2003
Duration
36 months
Abstract
The overall aim is to understand how cells and tissues are organised during vertebrate development. The project's specific aim is to understand how pattern formation in vertebrate limb buds lead to precise arrangement of individual muscles. We will explore two sequential steps in formation of individual muscles: global patterning signals & direct patterning of muscle primordia. In a mouse mutant for the homeobox gene Mox2, muscle and tendon pattern is altered but the skeleton is not. We will utilise mice mutant for Mox2 of Hox genes, and manipulations in the chick, to examine their function in muscle patterning and identify whether they act in the myogenic or connective tissue lineages.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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