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Molecular and functional analysis of the mutant mouse shaker-with-syndactylism
Reference
G11908
Principal Investigator / Supervisor
Professor Michael Dixon
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
224,836
Status
Completed
Type
Research Grant
Start date
01/10/1999
End date
19/09/2003
Duration
48 months
Abstract
The mutant mouse shaker-with-syndactylism (sy) exhibits digital fusions and hearing loss resulting from the deletion of a small segment of chromosome 18. Additional alleles of sy that exhibit either syndactylism or hearing loss have been described suggesting that the phenotype results from mutation of two genes. An integrative approach to investigate the sy phenotype will be used. Initially, two genes that map to the deletion will be analysed. If these genes are excluded, a positional cloning approach will be adopted. In parallel, functional analyses, using morphological, histological and molecular techniques, will be undertaken. These studies will provide insights into the fundamental events underlying digital development and hearing loss.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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