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Investigation of the role of the human FEN1 gene in genomic instability using inducible ribozyme gene ablation

Reference	G11906
Principal Investigator / Supervisor	Professor Kay Davies
Co-Investigators / Co-Supervisors
Institution	University of Oxford
Department	Human Anatomy and Genetics
Funding type	Research
Value (£)	145,708
Status	Completed
Type	Research Grant
Start date	01/05/2000
End date	01/05/2002
Duration	24 months

Abstract

Genetic instability in triplet arrays is of great biological interest as it represents a unique pathway which generates alleles with an increased mutational propensity. Attempts to model such instability in the mouse have only limited success but yeast studies have identified the FEN1 gene as playing a critical role in the fidelity of repeat array replication, suggesting that variations in its expression or activity might underlie instability in humans. We propose to examine the role of FEN1 in triplet array instability in human cells using state of the art gene ablation techniques. This will provide insights into human genome instability and serve as a model system in which similar genes can be easily studied.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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