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Transdifferentiation of visceral endoderm in the mouse
Reference
G11838
Principal Investigator / Supervisor
Professor Sir Richard Gardner
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Zoology
Funding type
Research
Value (£)
146,144
Status
Completed
Type
Research Grant
Start date
01/05/2000
End date
01/05/2003
Duration
36 months
Abstract
Transdifferentiation of visceral into parietal endoderm will be studied to find out if it depends on a change in the orientation of cytokinesis in visceral cells from parallel to orthogonal to their axis of polarity. The time-course of the process will be examined at both the cellular and molecular level and the orientation of mitoses at different stages determined by visceral- and parietal- specific genes by in situ hybridisation. Whether visceral cells can be made to transdifferentiate by experimentally altering the orientation of cytokinesis and whether they are able to form other types of cells will also be investigated.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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