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Essential and redundant roles of a PP1 isoform
Reference
G11827
Principal Investigator / Supervisor
Dr Luke Alphey
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Zoology
Funding type
Research
Value (£)
163,064
Status
Completed
Type
Research Grant
Start date
01/10/1999
End date
16/03/2003
Duration
41 months
Abstract
Type 1 serine/threonine protein phosphatases (PP1) are important regulators of many processes, including glycogen metabolism, muscle contraction, and the cell cycle. Both mammals and fruit flies have multiple genes encoding closely related (greater than 85 per cent identical). PP1 isoforms with indistinguishable activity in vitro, yet subtle sequence differences have been conserved over greater then 500 million years. So what are the unique and redundant roles of each of these isoform genes in vivo? I have mutants in three Drosophila PP1 genes, and propose a genetic approach to answering this question. As PP1 genes are highly conserved between species, insights obtained from Drosophila will be of wide relevance.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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