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Genome regulation during fungal morphogenesis
Reference
G11780
Principal Investigator / Supervisor
Professor Al Brown
Co-Investigators /
Co-Supervisors
Dr Phillip Cash
Institution
University of Aberdeen
Department
School of Medical Sciences
Funding type
Research
Value (£)
186,704
Status
Completed
Type
Research Grant
Start date
01/04/2000
End date
01/04/2003
Duration
36 months
Abstract
We are currently exploiting whole-genome microarrays to define specific changes in mRNA levels during pseudohyphal development in S. cerevisiae. In this project we will perform parallel analyses of the yeast proteome. Our specific objectives are (a) correlate specific changes in the yeast proteome and transcriptome during pseudohyphal development, (b) classify pseudohyphally regulated genes in terms of their regulatory profiles and functional characteristics, and (c) establish the roles of key signalling pathways in the control of gene expression during pseudohyphal development. In this way we will perform one of the first whole genome comparisons of developmental changes at the mRNA and protein levels to generate a comprehensive picture of gene regulation during cellular morphogenesis in yeast.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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