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Population bottlenecks changes in genetic variance and inbreeding depression in fruitflies
Reference
G11725
Principal Investigator / Supervisor
Professor Kevin Fowler
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Genetics Evolution and Environment
Funding type
Research
Value (£)
209,268
Status
Completed
Type
Research Grant
Start date
01/11/1999
End date
30/04/2003
Duration
42 months
Abstract
The pattern of changes in genetic variance after episodes of small population size and the genetic basis of inbreeding depression are poorly understood. Our experiments with fruitflies use quantitative genetic designs to (1) test a new theory that the increase of additive genetic variance after population bottlenecks is due to the genetic stress of inbreeding depression (2) separate epistasis from dominance in explaining changes in additive variance (3) distinguish between overdominance and dominance in causing inbreeding depression. The empirical approach involves measures of components of fitness using crosses both between and within inbred lines. The results will be significant in several contexts including speciation and conservation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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