Award details

Segmentation and morphogenesis of the vertebral column in the zebrafish embryo

Reference	G11720
Principal Investigator / Supervisor	Professor Roger Keynes
Co-Investigators / Co-Supervisors	Dr David Tannahill
Institution	University of Cambridge
Department	Physiology Development and Neuroscience
Funding type	Research
Value (£)	268,408
Status	Completed
Type	Research Grant
Start date	01/08/1999
End date	01/08/2002
Duration	36 months

Abstract

The vertebral column defines all vertebrates, yet it is unknown how the patterning of its segmental progenitors, the somites, is related to that of the mature vertebrae, or how the shapes of the individual vertebrae are defined. Vertebrae are suggested to result from resegmentation, whereby the sclerotome of neighbouring half-somites recombine. Tests of the resegmentation hypothesis are inconclusive, however, and the vertebral pattern may be determined by midline signals. We will exploit the advantages of the zebrafish embryo with a detailed lineage analysis of vertebral development in normal and mutant embryos. This work will provide the foundation for future studies of the molecular genetic basis of vertebral patterning.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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