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The origin of animals: a molecular genetic approach

Reference	G11719
Principal Investigator / Supervisor	Professor Peter Holland
Co-Investigators / Co-Supervisors
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	119,932
Status	Completed
Type	Research Grant
Start date	01/09/1999
End date	01/09/2002
Duration	36 months

Abstract

Collagen, laminin and clustered Hox-like genes are each hypothesised to be unique to, and universal within, Metazoa (multicellular animals). The first two are key components of basement membranes; the last plays a role in patterning a body axis. However, the existence of these characters has not been assessed in one the most basal Metazoa (Trichoplax) nor the metazoan outgroup (choanoflagellates). We will therefore (a) search for type IV collagen genes in both taxa, using PCR to a conserved motif, plus cDNA screening; (b) clone the ubiquitous p40 ribosomal protein from which arose the 67LR laminin receptor, and determine when laminin binding arose; (c) screen for Hox-like genes in choanoflagellates and walk out from the single known Trichoplax Hox-like gene to assess gene clustering; (d) construct new molecular phylogenies Hsp70 and cPKC protein-coding genes.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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