BBSRC Portfolio Analyser
Award details
FKHL gene cluster evolution in chordates
Reference
G11709
Principal Investigator / Supervisor
Professor Sebastian Shimeld
Co-Investigators /
Co-Supervisors
Institution
University of Reading
Department
Animal and Microbial Sciences
Funding type
Research
Value (£)
178,956
Status
Completed
Type
Research Grant
Start date
01/11/1999
End date
31/12/2002
Duration
38 months
Abstract
Clustering of related genes is common in vertebrates and is typically of recent evolutionary origin; exceptions, like the Hox cluster, reflect selective pressure to maintain cluster integrity. The FKHL genes are a family of transcription factors that show evidence of ancient clustering invertebrates. This proposal aims to establish the ancestral pattern of clustering of the FKHL genes in chordates and to investigate why clustering has been maintained in vertebrates. This will be done by using as models the genomes of organisms which are closely related to vertebrates, plus a combination of gene mapping, expression and transgenic techniques. This will increase our understanding of factors controlling genome organisation in vertebrates.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search