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Probing dynamic events on chromatin templates during transcription using surface plasmon resonance (SPR)

Reference	G11706
Principal Investigator / Supervisor	Professor Peter Stockley
Co-Investigators / Co-Supervisors	Professor Philip Gilmartin, Dr Celia Knight, Professor Peter Meyer
Institution	University of Leeds
Department	Inst of Molecular & Cellular Biology
Funding type	Research
Value (£)	242,628
Status	Completed
Type	Research Grant
Start date	16/03/1999
End date	16/09/2002
Duration	42 months

Abstract

We have developed a novel assay based on surface plasmon resonance for monitoring molecular recognition events and dynamic processes during in vitro transcription on chromatin templates. We propose to exploit this assay to a) probe the roles of a hormonally regulated bZIP transcription factor in the initiation of transcripts at the abscisic acid (ABA) regulated Em promoter; b) probe similar events controlled by a family of GATA factors at the light regulated rbcS-1A promoter, and c) probe the role of 'aberrant' RNAs in gene silencing.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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