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Characterisation of molecules that interact with commissureless
Reference
G11694
Principal Investigator / Supervisor
Professor Guy Justin Clive Tear
Co-Investigators /
Co-Supervisors
Institution
King's College London
Department
GKT School of Medicine
Funding type
Research
Value (£)
254,293
Status
Completed
Type
Research Grant
Start date
01/01/2000
End date
16/04/2003
Duration
40 months
Abstract
Commissureless encodes a novel gene product that is essential for normal development of the Drosophila central nervous system. In the absence of commissureless function the commissural axon pathways which join the two sides of the nervous system fail to form. It is evident that commissureless plays a central role in controlling axonal growth and may do so via the indirect regulation of cell surface molecules. In this proposal we aim to characterise how commissureless functions by identification of the molecules with which it interacts using expression cloning techniques. The commissureless interacting molecules will then be characterised and their role in neural development examined via the production of mutations and the directed misexpression of wild type and mutant forms of these proteins.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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