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A multidisciplinary study of the structure function and regulation of the eukaryotic initiation factor complex eIF4F
Reference
G11687
Principal Investigator / Supervisor
Professor John McCarthy
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
627,631
Status
Completed
Type
Research Grant
Start date
01/10/1999
End date
01/04/2003
Duration
42 months
Abstract
The cap-binding complex eIF4F plays a pivotal role in eukaryotic translation initiation. We will: 1. use genetics, SPR analysis and X-ray crystallography to characterise interactions within the eIF4F core complex (eIF4E:eIF4G) and between eIF4F and Poly(A)-binding protein (Pab1) and the regulatory eIF4E-binding proteins (p20/4E-BP); 2. determine the molecular mechanisms underlying the heterotrophic cooperativity modulating eIF4E-cap binding and the regulation of eIF4F via p20/4E-BP; 3. examine the global and mRNA- specific modulation of translation in response to changes in eIF4F activity caused by eIF4F mutations, nutrient-limitation and stress; and 4. test for cyclical eIF4F exchange during initiation using reconstruction methods.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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