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Structure and function of picornavirus cis-acting replication elements (CRE)
Reference
G11681
Principal Investigator / Supervisor
Professor David Evans
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Virology
Funding type
Research
Value (£)
184,558
Status
Completed
Type
Research Grant
Start date
01/07/1999
End date
01/07/2002
Duration
36 months
Abstract
A cis-acting replication element (CRE) has been identified in poliovirus. Similar RNA elements have been found in other positive strand RNA viruses, including bacteriophages, plant pathogens and animal viruses. To explore the hypothesis that all these viruses may replicate using an evolutionary conserved mechanism it is proposed to analyse the structure/function of the CRE in poliovirus; the prototype picornavirus and arguably the best studies RNA virus. Experiments are described to elucidate the structure of the stem-loop element, the functional domain(s), the identification of interacting viral/cellular proteins, the functional conservation of the element between different viruses and the defined role in replication and encapsidation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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