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How are neural stem cells maintained?
Reference
G10980
Principal Investigator / Supervisor
Professor Sarah Bray
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Physiology Development and Neuroscience
Funding type
Research
Value (£)
250,605
Status
Completed
Type
Research Grant
Start date
15/01/1999
End date
15/07/2002
Duration
42 months
Abstract
The post-embryonic neuroblasts (pNBs) in Drosophila have the properties of neural stem cells and thus provide a powerful system to investigate the mechanisms that preserve stem cells in their un-differentiated proliferative state. We propose to (1) determine the roles of Notch and other known signalling pathways in preventing differentiation and/or promoting proliferation of the pNB stem cells; (2) identify novel genes responsible for implementing the stem cell program in these cells. The results obtained will have implications for understanding the mechanisms that maintain the properties of all types of stem cells.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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