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Is telomere association the mechanism for plasmid transmission in yeast?
Reference
G10977
Principal Investigator / Supervisor
Professor James Murray
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Institute of Biotechnology
Funding type
Research
Value (£)
209,287
Status
Completed
Type
Research Grant
Start date
01/03/1999
End date
01/09/2002
Duration
42 months
Abstract
Segregation of DNA molecules normally occurs by attachment to the mitotic spindle by centromeres. We propose that the 2 micron plasmid of yeast segregates by an alternative mechanism of association with telomere sequences, and we present evidence based on plasmid protein localisation to support this model. We also demonstrate the feasibility of localising plasmid DNA molecules in cells to study plasmid segregation. Using combined cellular, genetic and biochemical approaches we will test the hypothesis of telomere-mediated plasmid segregation, and identify the chromosomally-encoded proteins required for plasmid segregation. We predict these genes may also be involved in telomere maintenance, silencing, clustering and perinuclear localisation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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