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Investigation of the pattern and mechanisms of cell movement during streak and node formation in early chick development
Reference
G10951
Principal Investigator / Supervisor
Professor Kees Weijer
Co-Investigators /
Co-Supervisors
Professor Andrea Munsterberg
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
161,952
Status
Completed
Type
Research Grant
Start date
01/08/1999
End date
01/08/2002
Duration
36 months
Abstract
These studies are directed towards understanding the control of cell movement during gastrulation in chick embryos. Initially we will obtain a detailed quantitative description of the patterns of cell movement during streak and node formation using digital, brightfield and fluorescence, time-lapse microscopy. We will label individual and groups of cells by micro- injection of fluorescent dyes, cell type specific antibodies and we will develop methods to express GFP in chimeric embryos. A detailed analysis of the cell movement patterns will indicate the control mechanisms involved. We will analyse the cell type specific, cell autonomous movement behaviour of isolated epiblast cells to assess their role in the collective behaviour during streak formation and gastrulation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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