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The molecular basis of anterior-posterior patterning and somite segmentation in the zebrafish

Reference	G10940
Principal Investigator / Supervisor	Professor Stephen Wilson
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Cell and Developmental Biology
Funding type	Research
Value (£)	179,977
Status	Completed
Type	Research Grant
Start date	01/07/1999
End date	17/12/2002
Duration	41 months

Abstract

Evidence from traditional embryological experiments and recent molecular analysis implicates an anterior-posterior prepattern mechanism as a crucial step in the formation of somite segmentation in the paraxial mesoderm of the vertebrate embryo. This application proposes to further our knowledge of the molecular basis of anterior-posterior prepatterning in three ways: i) to assess the role of Eph/ephrin signalling in creation of the somite boundary; ii) to assess the role of identified, and to be identified hairy related bHLH transcription factors in creating the anterior-posterior prepattern; iii) to perform a subtractive hybridisation screen using cDNA generated from wildtype and fused somite mutant embryos to identify novel genes involved in establishing the anterior-posterior somitic prepattern.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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