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Functional analysis of DPTEN the Drosophila homologue of the human tumour suppressor gene PTEN
Reference
G10924
Principal Investigator / Supervisor
Professor Clive Wilson
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Human Anatomy and Genetics
Funding type
Research
Value (£)
219,559
Status
Completed
Type
Research Grant
Start date
07/05/1999
End date
07/05/2002
Duration
36 months
Abstract
We have isolated a remarkably conserved Drosophila homologue of the human tumour suppressor gene PTEN, which encodes a cytoskeleton-associated phosphatase involved in cancer and several dominant genetic diseases. Our data already suggest this gene plays previously unsuspected roles in regulating cell size and invasiveness via a currently uncharacterised signalling pathway. Here, we propose to use Drosophila to determine PTENs key structural motifs and its precise functions in development and disease, using a combination of molecular genetic, cell biological and biochemical approaches. We will also employ genetic interaction screens to identify genes involved in PTEN signalling, which may represent future targets for therapy in advanced cancers.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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