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Derivation and analysis of mammary cell lines deficient in members of the STAT family of signalling factors
Reference
G10902
Principal Investigator / Supervisor
Professor Christine Watson
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Pathology
Funding type
Research
Value (£)
178,033
Status
Completed
Type
Research Grant
Start date
01/08/1999
End date
01/10/2002
Duration
38 months
Abstract
This work aims to use technology developed in this Laboratory to isolate, for the first time, novel mammary cell lines which have targeted disruptions of specific genes. This will be achieved using crosses between transgenic mice harbouring a conditional immortalising agent and knock-out mice which have targeted deletions of the genes encoding members of the STAT (signal transducer and activator of transcriptional) family. The regulation of differentiation and apoptosis in these STAT-deficient mammary cells will be investigated and functional domains, downstream target genes, and interactions with other signalling pathways identified. These cell lines will also provide a mechanism for assessing drug toxicity for breast cancer treatment.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
BioImaging (BI) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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