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A genetic study of the biological functions of platelet derived growth factor A
Reference
G10882
Principal Investigator / Supervisor
Professor J Heath
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
173,846
Status
Completed
Type
Research Grant
Start date
20/09/1999
End date
01/07/2003
Duration
45 months
Abstract
Mice which are homozygous for null alleles of the platelet-derived growth factor A (PDGF- A) gene die at, or shortly after birth, due to a deficiency of alveolar smooth muscle cells (SMCs). We wish to further examine the relationship between PDGF-A expression and SMC distribution during lung development. This will be achieved by expressing various forms of PDGF-A in the lung under the control of the lung surfactant protein C (spC) promoter which, like PDGF-A, is specifically expressed in the nascent alveolar epithelium. We propose to inter-cross these mice with PDGF-A+/- individuals to generate animals which only express PDGF-A in the lung. The ability to 'rescue' the lethal consequences of PDGF-A deficiency will enable us to determine the role of PDGF-A in postnatal development and physiology of other organs.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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