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The role of a putative myosin light chain in budding yeast
Reference
G10439
Principal Investigator / Supervisor
Dr Clive Price
Co-Investigators /
Co-Supervisors
Institution
Lancaster University
Department
Biological Sciences
Funding type
Research
Value (£)
168,860
Status
Completed
Type
Research Grant
Start date
01/03/1999
End date
01/07/2003
Duration
52 months
Abstract
We have identified a temperature sensitive mutation (mlc1-1) in a gene coding for a putative myosin light chain, MLC1. Preliminary phenotypic observations suggest that the protein plays a role in regulating actin/myosin cytoskeletal function. It is proposed to undertake a detailed cytological study of the terminal phenotype to establish the precise role of Mlc1p within the cell. This will include localisation of functional, monoclonal epitope tagged Mlc1p. We will characterise the proteins with which Mlc1p interacts using both genetic and biochemical approaches. Thereafter the possibility that the protein is regulated by calcium-dependent phosphorylation will be tested by genetic and biochemical experiments.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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