Award details

Models of codon substitution and detection of adaptive molecular evolution

Reference	G10434
Principal Investigator / Supervisor	Professor Ziheng Yang
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	146,537
Status	Completed
Type	Research Grant
Start date	15/04/1999
End date	31/07/2001
Duration	28 months

Abstract

Because mutation and selection have different effects on synonymous and nonsynonymous substitution rates, estimation of these rates from protein-coding DNA sequences provides an important tool to understand the mechanisms of molecular evolution. In this project, realistic models of DNA sequence evolution through codon substitution will be developed in the maximum likelihood framework. Important factors such as the codon usage bias and transition/transversion rate bias that have not been properly accounted for in earlier methods for pairwise comparison will be considered. The models will be further extended to account for variable selection intensity among amino acid sites and evolutionary lineages, and to detect positive selection at the molecular level. The new models will be implemented in a computer software and used to analyse molecular sequence data.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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