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Inferring the distribution of fitness effects of new mutations from DNA sequence data
Reference
G10138
Principal Investigator / Supervisor
Professor Adam Eyre-Walker
Co-Investigators /
Co-Supervisors
Institution
University of Sussex
Department
Biology and Environmental Science
Funding type
Research
Value (£)
113,649
Status
Completed
Type
Research Grant
Start date
01/04/1999
End date
01/04/2002
Duration
36 months
Abstract
Mutations are the ultimate source of all genetic variation. Unfortunately we do not know how frequently they occur, and what effects they have on fitness. This problem has been particularly evident in molecular evolution where the relative roles of genetic drift and selection have been debated for 30 years. The aim of the proposed research is to develop methods to estimate the distribution of fitness effects of new mutations from DNA sequence data (i.e. to estimate the proportions of mutations which are deleterious, neutral or advantageous, and the strength of selection which acts upon them) and to apply the methods to protein coding data.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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