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Inferring the distribution of fitness effects of new mutations from DNA sequence data

ReferenceG10138
Principal Investigator / Supervisor Professor Adam Eyre-Walker
Co-Investigators /
Co-Supervisors
Institution University of Sussex
DepartmentBiology and Environmental Science
Funding typeResearch
Value (£) 113,649
StatusCompleted
TypeResearch Grant
Start date 01/04/1999
End date 01/04/2002
Duration36 months

Abstract

Mutations are the ultimate source of all genetic variation. Unfortunately we do not know how frequently they occur, and what effects they have on fitness. This problem has been particularly evident in molecular evolution where the relative roles of genetic drift and selection have been debated for 30 years. The aim of the proposed research is to develop methods to estimate the distribution of fitness effects of new mutations from DNA sequence data (i.e. to estimate the proportions of mutations which are deleterious, neutral or advantageous, and the strength of selection which acts upon them) and to apply the methods to protein coding data.

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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