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Co-ordination of nuclear and kinetoplast gene expression during trypanosome differentiation
Reference
G10114
Principal Investigator / Supervisor
Professor Keith Matthews
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
167,967
Status
Completed
Type
Research Grant
Start date
18/01/1999
End date
18/01/2002
Duration
36 months
Abstract
Mitochondrial development is regulated during trypanosome differentiation. This requires the co-ordinated control of gene expression in both the nucleus and in the trypanosome's unusual mitochondrial genome (the kinetoplast). In this proposal, we will perturb the expression of either nuclear or kinetoplast encoded respiratory components and thereby determine: 1) The level of cross-talk between the nucleus and kinetoplast during trypanosome differentiation. 2) The impact of mitochondrial disruption upon other controlled events of the differentiation process.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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