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Studies on the translocation mechanism of telomerase
Reference
G09923
Principal Investigator / Supervisor
Professor Sir Shankar Balasubramanian
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
166,219
Status
Completed
Type
Research Grant
Start date
13/04/1999
End date
01/10/2002
Duration
42 months
Abstract
The telomere hypothesis postulated that the length of telomeres in cells is directly related to the processes of cell ageing and immortalisation. Telomerase is the RNA- dependent DNA polymerase responsible for the synthesis of telomeric DNA. This proposal seeks to study the mechanism of action of human telomerase and in particular the translocation mechanism which is unprecedented with other nucleic acid polymerases. The approaches used will employ the use of nucleic acid and nucleic acid mimetic probes to study putative intermediates in the mechanism and analyse the relevance of nucleic acid secondary structure to the mechanism.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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