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Activation targets in sigma-N
Reference
G09822
Principal Investigator / Supervisor
Professor Martin Buck
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
196,616
Status
Completed
Type
Research Grant
Start date
01/09/1998
End date
28/02/2002
Duration
42 months
Abstract
Protein footprints have been used to identify segments of sigma-N that become buried or change conformation upon binding to core RNA polymerase and to promoter DNA. It is proposed to mutagenise these segments and determine the associated defects in RNA polymerase function in order to correlate the protein footprint with mechanism of action and biological function of the sigma-N RNA polymerase. The aim is to determine the contributions of the sigma-core, sigma-DNA interfaces to steps of the RNA polymerase activation pathway.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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