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Novel ageing in Caenorhabditis elegans.
Reference
G09710
Principal Investigator / Supervisor
Dr Gordon. Lithgow
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
157,498
Status
Completed
Type
Research Grant
Start date
14/12/1998
End date
14/12/2001
Duration
36 months
Abstract
Ageing is a poorly understood process which occurs in almost all eukaryotes. We aim to describe normal ageing processes by mutational tagging and cloning of genes which limit the lifespan of the nematode, Caenorhabditis elegans. We have recently identified single-gene mutations which confer extended lifespan by a rapid screening method. Most of these mutations appear novel and are associated with enhanced stress resistance. We propose to identify the physiological alterations conferred by these mutations and hence describe processes contributing to normal aeging. This shall be achieved by molecular cloning of mutated genes and by analysis of altered gene expression in the mutant nematodes by microarray technology.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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