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Markov Chain Monte Carlo methods for sequence alignment and phylogeny reconstruction

Reference	G09600
Principal Investigator / Supervisor	Professor David Balding
Co-Investigators / Co-Supervisors	Dr Michael Denham, Professor Peter Holland
Institution	University of Reading
Department	Applied Statistics
Funding type	Research
Value (£)	114,412
Status	Completed
Type	Research Grant
Start date	01/01/1999
End date	01/07/2002
Duration	42 months

Abstract

We propose to develop fully probabilistic methods for phylogeny reconstruction of unaligned sequence data using Markov Chain Monte Carlo techniques. Statistical models which encapsulate the important features of the evolutionary process including base substitutions and insertion/deletion events will be investigated and the sensitivity of inferences based on such assumptions assessed. The methodology will be applied to the use of DNA in investigating developmental and body plan evolution, and investigating genome history.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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