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Transcription activation by E. coli Melr protein.
Reference
G09595
Principal Investigator / Supervisor
Professor Steve Busby
Co-Investigators /
Co-Supervisors
Dr Eva Hyde
Institution
University of Birmingham
Department
Sch of Geography, Earth & Env Sciences
Funding type
Research
Value (£)
157,373
Status
Completed
Type
Research Grant
Start date
01/08/1998
End date
01/08/2001
Duration
36 months
Abstract
MelR is a transcription activator belonging to the AraC family of bacterial transcription factors. We propose to use a combination of molecular genetics and biochemistry to investigate four fundamental questions concerning the function of MelR (and other members of the family): (1) how does MelR interact with DNA? (2) what is the role of MelR binding at different target sites? (3) how does MelR interact with RNA polymerase to activate the melAB promoter? (4) does MelR interact with other transcription factors?
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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