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Strategies for purging inbreeding depression.
Reference
G09540
Principal Investigator / Supervisor
Professor William George Hill
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Inst of Cell, Animal and Population Biol
Funding type
Research
Value (£)
61,340
Status
Completed
Type
Research Grant
Start date
27/05/1998
End date
27/05/2000
Duration
24 months
Abstract
The proposed research will use the valuable published information on mutation parameters to obtain the frequency distributions of mutants of various effects and dominance coefficients in populations in mutation-selection balance by diffusion approximations under the infinite sites model. We will propose several inbreeding, selection and structure strategies and investigate their effects on purging the genetic load or inbreeding depression maintained in equilibrium populations. The most appropriate strategy which is efficient in purging lethal and deleterious mutants without much risk of extinction in both the short and long term will be sought. This issue is important in developing inbred lines in plant and animal breeding, in conserving endangered wild species and domestic breeds and in understanding the process of evolution.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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