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Identification of genes involved in haematopoietic stem cell differentiation during embryonic development of the mouse
Reference
G09505
Principal Investigator / Supervisor
Professor Alexander Medvinsky
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Inst of Stem Cell Research
Funding type
Research
Value (£)
207,824
Status
Completed
Type
Research Grant
Start date
20/05/1998
End date
18/10/2001
Duration
41 months
Abstract
At the foundation of the hematopoietic hierarchy lies the pluripotent hematopoietic stem cell (HSC). Recently we have identified the region in which HSCs first differentiate in the mouse embryo (the AGM region). Our preliminary data show that none of the known hematopoietic growth factors are responsible for this process, suggesting that the stromal microenvironment of the AGM region contains novel secreted/membrane-associated molecule(s) inducing HSC differentiation. The present proposal aims to investigate the pattern of expression of genes in the AGM region and to identify those responsible for the process of HSC differentiation. An efficient strategy for generating an enriched cDNA library will reduce substantially the number of candidate genes. Our screening strategy includes primary candidate gene selection following by direct functional screen.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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