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Consequences of mutation accumulation for fitness traits

Reference	G09423
Principal Investigator / Supervisor	Professor Peter Keightley
Co-Investigators / Co-Supervisors	Professor Nicholas Barton
Institution	University of Edinburgh
Department	Inst of Cell, Animal and Population Biol
Funding type	Research
Value (£)	172,915
Status	Completed
Type	Research Grant
Start date	01/09/1998
End date	30/11/2001
Duration	39 months

Abstract

Genome wide mutation rates and distribution of mutation effects are central for several important questions in evolutionary and population biology, but most information is currently limited to Drosophila melanogaster. To extend our knowledge, we propose to study the effects of the accumulation of mutations on fitness traits in C. elegans in circumstances where the number of events at the DNA level can be estimated. We shall compare the distributions of effects of transposable element and chemically induced mutations, and make inferences about their epistatic, genotype x environment interactions, and pleiotropic effects for life history traits.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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