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Genetics of body size

Reference	G09307
Principal Investigator / Supervisor	Professor Linda Partridge
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	75,287
Status	Completed
Type	Research Grant
Start date	01/01/1998
End date	01/07/1999
Duration	18 months

Abstract

Control of body size is of central importance in development, evolution and selective breeding. Almost nothing is known, for any multicellular organism, of the mechanisms responsible for targeted growth, integration of cell proliferation and patterning, regulation of cell expansion or co-ordinated regulation of the size of different anatomical regions of the body. This study aims to map and identify genes involved in co-ordinating growth and size in a model organism, the fruitfly Drosophila melanogaster. Methods to be used are: (a) analysis of recombinant inbred (RI) lines derived from lines artificially selected for body size and (b) analysis of a similar set of lines derived from populations diverged in body size through natural selection in the wild. In both cases, preliminary mapping will be followed by fine-scale mapping and complementation analysis with mutants in candidate genes.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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