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Protein-induced DNA bending by MADS-box transcription factors
Reference
G09239
Principal Investigator / Supervisor
Professor Andrew Sharrocks
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
158,319
Status
Completed
Type
Research Grant
Start date
23/04/1998
End date
23/04/2001
Duration
36 months
Abstract
Protein-induced DNA bending is thought to be important for the correct juxtapositioning of transcription factors on promoters. In addition, DNA-bending may also play a role in promoter recognition. Members of the MADS-box transcription factor family exhibit differential abilities to bend DNA. The aim of this project is to investigate how protein- induced DNA bending is achieved and to address the physiological significance of DNA- bending in the activation of transcription in vivo. Studies will be concentrated on three MADS-box proteins, SRF, MCM1 and SQUA due to differences in their DNA bending/binding mechanisms and suitability for in vivo studies. By combining our results on these three proteins, we aim to develop a comprehensive model for how MADS-box proteins bend DNA and to develop several systems in which our predictions can be tested in vivo.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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