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Investigation of the molecular mechanism of genetic regulation by thiamine in yeast
Reference
G08756
Principal Investigator / Supervisor
Dr Peter Anthony Meacock
Co-Investigators /
Co-Supervisors
Institution
University of Leicester
Department
Genetics
Funding type
Research
Value (£)
162,367
Status
Completed
Type
Research Grant
Start date
20/10/1997
End date
20/10/2000
Duration
36 months
Abstract
This project seeks to understand how, in the bakers' yeast Saccharomyces cerevisiae, thiamine (vitamin B1) represses transcription of several genes encoding enzymes of its own biosynthetic pathway, as well as an acid phosphatase and one iso-form of the important thiamine diphosphate-dependent enzyme pyruvate decarboxylase, it will examine the interactions between three positive regulator proteins (Thi2, Thi3 and Pdc2) and of these with gene promoter elements that exert transcriptional control, and will study how mutations in these genes affect parts of metabolism subject to thiamine dependency/control.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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