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Genetic analysis of quantitative traits

Reference	G08646
Principal Investigator / Supervisor	Professor William George Hill
Co-Investigators / Co-Supervisors	Professor Grahame Bulfield, Professor Peter Keightley
Institution	University of Edinburgh
Department	Inst of Cell, Animal and Population Biol
Funding type	Research
Value (£)	218,502
Status	Completed
Type	Research Grant
Start date	01/01/1998
End date	31/03/2000
Duration	27 months

Abstract

We have established a unique set of lines of mice by 60 generations of selection over a period of 17 years for growth, fatness and feed intake, and have brought in selected lines from labs elsewhere. These are an important resource for mapping quantitative trait loci (QTL) and identifying the relevant genes. The aim is to maintain and further develop this resource by inbreeding the selection lines to facilitate QTL detection, development of congenic backcross lines by selection to isolate QTL of large effect, and testing for candidate genes. Separate applications will be made for other studies, such as fine-scale QTL mapping and investigation of factors associated with the selection response, e.g. leptin.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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