BBSRC Portfolio Analyser
Award details
Morphogenetic signalling by desmosomal glycoproteins in epidermal development
Reference
G08620
Principal Investigator / Supervisor
Professor Carolyn Ruth Byrne
Co-Investigators /
Co-Supervisors
Professor David Garrod
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
177,975
Status
Completed
Type
Research Grant
Start date
01/05/1998
End date
31/12/2001
Duration
41 months
Abstract
Desmosomal glycoproteins are cadherin-like components of the desmosome - a major adhesive junctional component of epithelial cells. We recently analysed expression of desmocollins, a class of desmosomal glycoproteins, during development and differentiation of epidermis. Our results show differential distribution of glycoproteins between layers of the skin, leading us to predict a grading of adhesive properties that has consequences for cell positioning and differentation in epidermis. We will test this by disrupting the pattern of desmosomal glycoprotein expression in transgenic animals. Analysis of the consequent development, morphology and differentation of epidermis will provide insights into desmosome function and epidermal differentiation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search