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Molecular mechanisms controlling antler regeneration
Reference
G08574
Principal Investigator / Supervisor
Professor Joanna Price
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Medicine
Funding type
Research
Value (£)
159,027
Status
Completed
Type
Research Grant
Start date
19/01/1998
End date
19/01/2001
Duration
36 months
Abstract
The antlers of red deer regenerate each year from a blastema into complex branched structures by an endochondral process. In this study we will test the hypotheses (i) that the molecular signals which mediate epithelial-mesenchymal interactions in the regenerating antler are similar to those that play a role in embryonic limb development (ii) that the expression of these signals is influenced by hormones and (iii) that during antler regeneration the osteogenic potential of a range of mesenchymal cells is influenced by circulating sex hormones. The expression of FGF-4, BMPs 2&4, Sonic and Indian Hedgehog, Msx-1 & Msx-2 will be studied in antlers at selected stages of growth, and when the hormonal environment is manipulated. The effects of growth factors, retinoic acid and epithelium on the differentiation of cultured blastema cells will be studied. The osteogenic potential of different cell types will be determined in vitro and then in vivo using the diffusion chamber assay.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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