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Identification and characterisation of an ectodermally derived forebrain organising signal in the zebrafish gastrula

Reference	G08038
Principal Investigator / Supervisor	Professor Stephen Wilson
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Cell and Developmental Biology
Funding type	Research
Value (£)	206,537
Status	Completed
Type	Research Grant
Start date	15/05/1997
End date	15/05/2000
Duration	36 months

Abstract

We have recently discovered that anteroposterior patterning of the zebrafish forebrain depends upon a previously uncharacterised signal released during gastrulation by cells located at the anterior edge of the prospective neural plate. This proposal will assess how and when the signal regulates regional patterning and neurogenesis, and will define the limit of its activity within the neural plate. Genes specifically expressed in the forebrain organiser will be isolated and their role in brain patterning investigated. Genetic mutations affecting the organiser or the tissue responding to the organiser signal will be characterised. Finally, it will be determined whether the forebrain organiser is conserved between vertebrates.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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