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Transcription activation at class 1 CRP-dependent promoters
Reference
G07974
Principal Investigator / Supervisor
Professor Steve Busby
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Geography, Earth & Env Sciences
Funding type
Research
Value (£)
174,308
Status
Completed
Type
Research Grant
Start date
01/06/1997
End date
01/06/2000
Duration
36 months
Abstract
Transcription activation at Class I promoters dependent on the Escherichia coli cyclic AMP receptor protein (CRP) is dependent upon a single direct interaction between a surface- exposed activating region in CRP and a contact site in the C-terminal domain of the RNA polymerase alpha subunit (alphaCTD). We propose to identify the contact site for this activating region in alphaCTD, to quantify CRP:alphaCTD interactions and to investigate the consequences of this interaction. Finally, we plan to investigate the organisation of alphaCTD subunits at promoters carrying the DNA site for CRP at different locations upstream of the RNAP-binding elements.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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