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Evolution of RNA-sequence structure and function
Reference
G07945
Principal Investigator / Supervisor
Professor Paul Higgs
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
106,846
Status
Completed
Type
Research Grant
Start date
10/11/1997
End date
31/12/2000
Duration
38 months
Abstract
We will use a combination of analytical theory and computer simulations to describe the evolution of RNA sequences. We will calculate the expected distribution of functional sequences in sequence space, and compare this with sequence data from experiments selecting for ribozymes using partially randomised RNA pools. We will predict which parameters and which experimental variants are likely to be most successful in yielding high fitness sequences. We will calculate the rate at which mutations are likely to accumulate in naturally evolving RNA sequences where selection is acting to maintain a particular secondary structure, and we will use this theory to analyse the pattern of sequence variation seen in databases of tRNA and rRNA sequences.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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